SiRNA Design & Screening
siRNA Design & Screening
Our siRNA platform combines computational design with experimental validation to deliver highly potent and specific gene silencing solutions. From initial target identification to lead optimization, we provide comprehensive support for your RNAi research and therapeutic development.
Core Capabilities
- Computational Design: Advanced algorithms predict siRNA efficacy, specificity, and potential off-target effects
- Library Screening: Custom and genome-wide siRNA library screening services
- Chemical Optimization: Tailored modification patterns for enhanced stability and potency
Applications
- Functional genomics research
- Drug target validation
- Therapeutic siRNA development
- Agricultural biotechnology
Key Features
-
Target Design & Prediction
Bioinformatics-driven siRNA design with off-target prediction and specificity scoring.
-
High-Throughput Screening
Automated screening platform for rapid identification of potent siRNA candidates.
-
Modification & Validation
Chemical modification optimization and comprehensive in vitro/in vivo efficacy validation.
Technical Capabilities
- siRNA design algorithms (Thermo, siDirect)
- Off-target prediction (BLAST, seed region analysis)
- Chemical modification (2'-OMe, 2'-F, PS backbone)
- High-throughput transfection screening
- qPCR/Western blot validation
- In vivo delivery formulation